About

Introduction

NEXT 3D is a groundbreaking simulation tool designed to optimize nanoparticle research for glioblastoma treatment. It provides researchers with an innovative platform to test and refine therapeutic strategies without the need for extensive laboratory experiments.

Motivation

Glioblastoma multiforme, one of the most aggressive brain cancers, presents significant challenges in treatment, particularly in delivering therapeutic agents across the blood-brain barrier (BBB). Recognizing the inefficiencies of traditional methods, NEXT 3D was developed to bridge this gap, inspired by a combined passion for neuroanatomy and computational modeling.

Engineering Criteria

The development process emphasized accuracy, robustness, and modularity in its engineering criteria, derived from feedback from medical and computational experts that called for a tool that allows rapid development and customization.

Specifications

Dependencies

All dependencies are automatically installed with NEXT 3D except for those marked otherwise.

Platforms/Operating Systems

This software has been tested on MacOS Sequoia 15.0.1. Functionality is not guaranteed but expected on other platforms.

Installation

The tool will be available for free on GitHub.
File size is approximately 1.5 GB.

Conclusions

By offering detailed simulations of nanoparticle dynamics, NEXT 3D accelerates the development of effective glioblastoma treatments. This tool reduces reliance on animal testing, fosters innovation, and supports collaborative research across disciplines.

Future Directions

NEXT 3D aims to expand its capabilities with:

Frequently Asked Questions

When am I supposed to use NEXT 3D?

NEXT 3D is designed for researchers who want to test and refine therapeutic strategies without the need for extensive laboratory experiments. Results generated in simulation can not be assumed for clinical use; accuracy is not guaranteed. Positive simulation results should be followed up with in vitro and in vivo studies prior to clinical usage. Laboratory studies conducted after simulation usage must cite NEXT 3D.

How can I access NEXT 3D?

NEXT 3D is open-source and will be available at its GitHub repository. You will find installation and usage instructions there.

I am seeking a license allowing me to modify NEXT 3D into a new and separate software.

A modification license (commercial or non-commercial) exists for researchers who wish to modify NEXT 3D into a new and separate software. The license is available for a one-time purchase per individual (non-commercial) or per institution (commercial). Please contact contact[at]next-3d.com for information regarding purchasing a license.
Note: The modification license does not allow you to distribute NEXT 3D as a separate software. You will need to distribute your own modified version of NEXT 3D. For security reasons, those who purchase the modification license will be publicly listed.

How do I request written permission (e.g. figures)?

Permission requests can be emailed to contact[at]next-3d.com. Please include the name of the researcher, what you are requesting, how you intend to use it, and the reason for your request in the email body. Please note that permission requests are not guaranteed. If you are unable to obtain permission, please contact the author directly.

Can I contribute to NEXT 3D?

Yes, contributions are welcome! You can submit pull requests or suggest features through the GitHub repository.

What is the license?

NEXT 3D is distributed under the CC-BY-NC-ND license, making it free for non-commercial use with attribution required. For more information, please refer to the LICENSE file.