NEXT 3D

Overview

NEXT 3D is an advanced simulation tool developed to revolutionize preclinical testing of nanoparticles in glioma treatment. By simulating nanoparticle interactions with the BBB and tumor microenvironment, NEXT 3D eliminates the inefficiencies of repetitive in vivo trials by providing nanoparticle behavior metrics. Its modular architecture empowers researchers to customize the tool for diverse therapeutic scenarios, including thermotherapy and drug delivery applications.

Highlights

Real-Time 3-D Simulation: Evaluate nanoparticle-BBB interactions in a three-dimensional, locomotive, virtual environment.
Intuitive Visual Feedback: Visualize metrics with dynamically adjusting color schemes to understand step-by-step progression that physical tests won't show.
Validated Accuracy: Benchmarked against published literature for in vitro and in vivo studies to ensure accuracy in simulation methods.*
Plugin-Based Customization: Expand the platform's functionality through custom development, and push your codebase to the community-managed plugin portal.
Thermotherapeutic In Silico Testing: Track thermal conductivity and temperature effects on glioma cells with the preinstalled plugin's novel regionalization methodology.

Evaluation

NEXT 3D provides high-resolution visualizations of key metrics such as nanoparticle permeability, retention rates, and localized thermal effects. Researchers can upload and review their own simulation data for collaborative analysis.

Licenses and Credits

The code for this project will be accessible on GitHub.
This software, as with all subsequent versions of the software, is protected by the CC-BY-NC-ND license. In summary, this does not allow commercial usage, distribution, or distribution of modifications of the software. In additon, you are required to credit authorship and state any changes you may have made. For more information, please refer to the LICENSE file.
This project was developed by Aarav H. Dave. For more information, please visit Contact.